Publications and Patents

CMC Research Team Publications

• Cosenza, Z., Astudillo, R., Frazier, P. I., Baar, K., & Block, D. E. (2022). Multi‐information source Bayesian optimization of culture media for cellular agriculture. Biotechnology and Bioengineering, 119(9), 2447–2458.  

• Cosenza, Z., Block, D. E., & Baar, K. (2021). Optimization of muscle cell culture media using nonlinear design of experiments. Biotechnology Journal, 16(11), 2100228.

• Kelada, K. D., Tusé, D., Gleba, Y., McDonald, K. A., & Nandi, S. (2021). Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II. Foods, 10(4), 838.

• Lee, H. & Sumner, D. A. Demand for Plant-Based Meat and Cultivated Meat: Evidence from a Large Sample of U.S. Buyers. 2023 Annu. Meet. July 23-25 Wash. DC (2023).

• McNulty, M. J., Kelada, K., Paul, D., Nandi, S., & McDonald, K. A. (2021a). Introducing uncertainty quantification to techno-economic models of manufacturing field-grown plant-made products. Food and Bioproducts Processing, 128, 153–165.

• McNulty, M. J., Kelada, K., Paul, D., Nandi, S., & McDonald, K. A. (2021b). Techno-economic process modelling and Monte Carlo simulation data of uncertainty quantification in field-grown plant-based manufacturing. Data in Brief, 38, 107317.

• McNulty, M. J., Nandi, S., & McDonald, K. A. (2022). Technoeconomic Modeling and Simulation for Plant-Based Manufacturing of Recombinant Proteins. In S. Schillberg & H. Spiegel (Eds.), Recombinant Proteins in Plants (Vol. 2480, pp. 159–189). Springer US.

• McNulty, M. J., Silberstein, D. Z., Kuhn, B. T., Padgett, H. S., Nandi, S., McDonald, K. A., & Cross, C. E. (2021). Alpha-1 antitrypsin deficiency and recombinant protein sources with focus on plant sources: Updates, challenges and perspectives. Free Radical Biology and Medicine, 163, 10–30.

• Negulescu, P. G., Risner, D., Spang, E. S., Sumner, D., Block, D., Nandi, S., & McDonald, K. A. (2023). Techno-Economic Modelling and Assessment of Cultivated Meat: Impact of Production Bioreactor Scale. Biotechnol Bioeng.;120:1055–1067.

• Ogawa, M.; Moreno García, J.; Nitin, N.; Baar, K.; Block, D.E. Assessing Edible Filamentous Fungal Carriers as Cell Supports for Growth of Yeast and Cultivated Meat. Foods 2022, 11, 3142. 

• O'Neill, E. N., Cosenza, Z. A., Baar, K., & Block, D. E. (2020). Considerations for the Development of Cost-Effective Cell Culture Media for Cultivated Meat Production. Comprehensive Reviews in Food Science and Food Safety, 20(1): 686-709.

• O’Neill, E.N., Ansel, J.C., Kwong, G.A. et al. Spent media analysis suggests cultivated meat media will require species and cell type optimization. npj Sci Food, 6, 46 (2022).

• O'Neill, E. N., Neffling, M., Randall, N., Kwong, G., Ansel, J. Baar, K. and Block, D. E. (2023). The effect of serum-free media on the metabolic yields and growth rates of C2C12 cells in the context of cultivated meat production. Future Foods, 7, June 2023, 100226.

• Risner, D.; Li, F.; Fell, J.S.; Pace, S.A.; Siegel, J.B.; Tagkopoulos, I.; Spang, E.S. (2021). Preliminary Techno-Economic Assessment of Animal Cell-Based Meat. Foods, 10, 3. 

• Risner, D., McDonald, K. A., Jones, C. & Spang, E. S. A techno-economic model of mycoprotein production: achieving price parity with beef protein. Front. Sustain. Food Syst. 7, (2023).

Related UC Davis Publications

• Fok, S. W., Greshham, R. C. H., Ryan, W., Osipov, B., Bahney, C., Leach, J. K. Macromolecular crowding and decellularization method increase the growth factor binding potential of cell-secreted extracellular matrices. Front. Bioeng. Biotechnol. 11, (2023).
• Minami, S. A. & Shah, P. S. Computational evaluation of light propagation in cylindrical bioreactors for optogenetic mammalian cell cultures. bioRxiv 2023–02 (2023).

CMC Research Team Patents

• Ogawa, M., & Block, D. E. (provisional). Compositions including filamentous fungal biomass and cultured animal cells, and methods of forming and using. (Patent No. 0652.000004US60).